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KMID : 0881720220370020114
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Journal of Food Hygiene and Safety
2022 Volume.37 No. 2 p.114 ~ p.120
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Comparative Study of Dissolution Properties of Immediate-release and Controlled-release Type Vitamin C Tablets
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Yang Hyo-Jin
Ryu Na-Hee
Yang Joo-Hong
Hong Sun-Ho
Lee Yeon-Kyung
Cho Yang-Hee
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Abstract
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In this study, a comparative dissolution experiment was conducted between an immediate-release and a controlled-release vitamin C tablet applied with a technology to control the dissolution of vitamin C to maintain the vitamin C level in the human body. In order to confirm the dissolution rate (%) of vitamin C tablets, HPLC determination was conducted based on the dissolution test methods in the ‘Korean Pharmacopoeia (No. 2020-88),’ ‘Guidelines on Specifications of Dissolution Tests for Oral dosage Forms,’ and ‘Standard and Specifications for Health Functional Foods (No. 2020-63)’ from Ministry of Food and Drug Safety (MFDS). In addition, the dissolution pattern between the immediate-release tablet and the controlled-release tablet was comparatively analyzed. The analysis result confirmed that the immediate-release vitamin C tablet was 100% dissolved after 45 minutes, while the controlled-release vitamin C tablet was 100% dissolved after 480 minutes (8 hours). Furthermore, the dissolution rate (%) at 60 minutes was slower than that of the immediate-release vitamin C tablet. Based on these results, this study confirmed that the dissolution rate (%) test and development of controlled-release tablets containing vitamin C as the main component a re possible.
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KEYWORD
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Vitamin C, Controlled release, Immediate release, HPLC
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